Solutions by Therapeutic Area
Ophthalmology
We provide comprehensive preclinical research services to support the development of ophthalmic therapies. With precise drug administration techniques and advanced analytical methods, we evaluate the safety and distribution of therapeutic agents, ensuring their suitability and potential for successful development.
Our specialized drug administration techniques include Intravitreal Injection, Subconjunctival Injection, and Subretinal Injection, tailored to ophthalmology-specific needs to thoroughly analyze local toxicity and tissue distribution.
Ophthalmology FAQs
What analytical techniques are used for distribution studies?
- ELISA (Enzyme-Linked Immunosorbent Assay): Precisely measures the concentration of drugs and cytokines in tissues.
- ECL (Electrochemiluminescence): Provides high-sensitivity quantification of inflammatory mediators and drug distribution.
qPCR (Quantitative Real-Time PCR): Analyzes gene expression levels to evaluate drug distribution and inflammatory responses in detail.
What are the key parameters evaluated in toxicity studies?
- Ocular Tissue Histopathology: Assesses inflammation and cellular damage in retinal, choroidal, and corneal tissues.
- Intraocular Pressure (IOP): Monitors changes in eye pressure following drug administration to ensure safety.
- Systemic Toxicity: Evaluates drug distribution beyond the eye to assess systemic exposure and safety.